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Effects

Long COVID

Sudre, C.H., Murray, B., et al. 2020. “Attributes and predictors of Long-COVID: analysis of COVID cases and their symptoms collected by the Covid Symptoms Study App.” medRxiv 2020.10.19.20214494.

Reports of “Long-COVID”, are rising but little is known about prevalence, risk factors, or whether it is possible to predict a protracted course early in the disease. We analysed data from 4182 incident cases of COVID-19 who logged their symptoms prospectively in the COVID Symptom Study app. 558 (13.3%) had symptoms lasting >=28 days, 189 […]

Cardiac

Long-term cardiovascular outcomes of COVID-19. Nat Med (2022)

Xie, Y., Xu, E., Bowe, B. et al. Long-term cardiovascular outcomes of COVID-19. Nat Med (2022). https://www.nature.com/articles/s41591-022-01689-3 The cardiovascular complications of acute coronavirus disease 2019 (COVID-19) are well described, but the post-acute cardiovascular manifestations of COVID-19 have not yet been comprehensively characterized. Here we used national healthcare databases from the US Department of Veterans Affairs to build a […]

Neurological

Baig, A.M. “Counting the neurological cost of COVID-19.” Nat Rev Neurol 18, 5–6 (2022)

Baig, A.M. Counting the neurological cost of COVID-19. Nat Rev Neurol 18, 5–6 (2022). https://doi.org/10.1038/s41582-021-00593-7 The neurological deficits caused by COVID-19, which were first reported in the early months of 2020, continue to intrigue neurologists and health-care professionals worldwide. As two new studies highlight, these manifestations are frequent and are expected to increase the burden of morbidity and […]

“The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.” Nature Neuroscience volume 24, pages1522–1533 (2021)

Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause neurological symptoms. Here we describe structural changes in cerebral small vessels of patients with COVID-19 and elucidate potential mechanisms underlying the vascular pathology. In brains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals and animal models, we found an increased number of empty […]

de Erausquin, GA, Snyder, H, Carrillo, M, et al. 2021. “The chronic neuropsychiatric sequelae of COVID‐19: The need for a prospective study of viral impact on brain functioning.” Alzheimer’s & Dementia, 2021; 1– 9.

Introduction The increasing evidence of SARS‐CoV‐2 impact on the central nervous system (CNS) raises key questions on its impact for risk of later life cognitive decline, Alzheimer’s disease (AD), and other dementia. Methods The Alzheimer’s Association and representatives from more than 30 countries—with technical guidance from the World Health Organization—have formed an international consortium to […]

neuro effects

Nath, A., and Smith, B. 2021. “Neurological issues during COVID-19: An overview.” Neuroscience Letters Volume 742, 135533.

COVID-19 has shaken the core of the medical health system. The wide spread death and destruction of patients and health care workers in unprecedented in the modern era. While the pulmonary complications have received the most attention, it is the neurological manifestations that are disabling, persistent and common in patients infected with SARS-CoV-2. The entire […]

Nath, A. and Smith, B., 2020. “Neurological issues during COVID-19: An overview.” Neuroscience Letters, 2020, 135533, ISSN 0304-3940.

COVID-19 has shaken the core of the medical health system. The wide spread death and destruction of patients and health care workers in unprecedented in the modern era. While the pulmonary complications have received the most attention, it is the neurological manifestations that are disabling, persistent and common in patients infected with SARS-CoV-2. The entire […]

Pediatric

Campbell, D. and Bannock, C. 2021. “Up to 100 UK children a week hospitalised with rare post-Covid disease.” The Guardian UK, Fri 5 Feb 2021

Up to 100 children a week are being hospitalised with a rare disease that can emerge weeks after Covid-19, leaving them in intensive care, doctors have said. In a phenomenon that is worrying paediatricians, 75% of the children worst affected by paediatric inflammatory multi-system syndrome (PIMS) were black, Asian or ethnic minority (BAME). Almost four […]

Auger, K.A., Shah, S.S., et al. 2020. “Association Between Statewide School Closure and COVID-19 Incidence and Mortality in the US.” JAMA. 2020;324(9):859–870.

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Question  Was statewide school closure associated with decreased incidence and mortality for coronavirus disease 2019 (COVID-19)? Findings  In this US population–based time series analysis conducted between March 9, 2020, and May 7, 2020, school closure was associated with a significant decline in both incidence of COVID-19 (adjusted relative change per week, −62%) and mortality (adjusted relative change […]